Publication Highlights

Differential Effects of Lipid and Redox Modulators on Colitis and Colitis-associated Cancer (CAC)

Franziska Moll, Maria Walter, Flávia Rezende, Valeska Helfinger, Estefania Vasconez,Tiago De Oliveira, Florian R. Greten, Catherine Olesch, Andreas Weigert, Heinfried H. Radeke, and Katrin Schröder: NoxO1 Controls Proliferation of Colon Epithelial Cells. Frontiers in Immunology 05/2018; 9;973, DOI:10.3389/fimmu.2018.00973

Cornelia Richter, Martina Herrero San Juan, Benno Weigmann, Dominik Bergis, Katrin Dauber, Michael H Muders, Gustavo B Baretton, Josef M Pfeilschifter, Halvard Bonig, Sebastian Brenner, Heinfried H Radeke: Defective IL-23/IL-17 Axis Protects p47phox−/− Mice from Colon Cancer. Frontiers in Immunology 01/2017; 8(44)., DOI:10.3389/fimmu.2017.00044

Stephanie Oertel, Klaus Scholich, Andreas Weigert, Dominique Thomas, Julia Schmetzer, Sandra Trautmann, Marthe-Susanna Wegner, Heinfried H. Radeke, Natalie Filmann, Bernhard Brüne, Gerd Geisslinger, Irmgard Tegeder, Sabine Grösch: Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cellular and Molecular Life Sciences 2017 Aug;74(16):3039-3055. doi: 10.1007/s00018-017-2518-9. Epub 2017 Apr 12.

Katja Zschiebsch, Caroline Fischer, Geethanjali Pickert, Annett Häeussler, Heinfried Radeke, Sabine Grösch, Nerea Ferreirós, Gerd Geisslinger, Ernst R. Werner, Irmgard Tegeder: Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling. Journal of Crohn s and Colitis 02/2016; 10(8):jjw056., DOI:10.1093/ecco-jcc/jjw056

Carolin Daniel, Nico Sartory, Nadine Zahn, Gerd Geisslinger, Heinfried H. Radeke, Juergen M. Stein: FTY720 Ameliorates Th1-Mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4+CD25+ Regulatory T Cells. Journal of Immunology 2007 Feb 15;178(4):2458-68



Peer-Reviewed Publications

2018

Franziska Moll, Maria Walter, Flávia Rezende, Valeska Helfinger, Estefania Vasconez,Tiago De Oliveira, Florian R. Greten, Catherine Olesch, Andreas Weigert, Heinfried H. Radeke, and Katrin Schröder: NoxO1 Controls Proliferation of Colon Epithelial Cells. Frontiers in Immunology 05/2018; 9;973, DOI:10.3389/fimmu.2018.00973

Madalina-Viviana Nastase, Jinyang Zeng-Brouwers, Janet Beckmann, Claudia Tredup, Urs Christen, Heinfried H. Radeke, Malgorzata Wygrecka, Liliana Schaefer: Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney. Matrix Biology, 15 December 2017. pii: S0945-053X(17)30427-4. doi: 10.1016/j.matbio.2017.12.002. [Epub ahead of print]

Anja Schwiebs, Dominique Thomas, Burkhard Kleuser, Josef M. Pfeilschifter, Heinfried H. Radeke: Nuclear Translocation of SGPP-1 and Decrease of SGPL-1 Activity Contribute to Sphingolipid Rheostat Regulation of Inflammatory Dendritic Cells. Mediators of Inflammation, December 2017(2):1-10 DOI10.1155/2017/5187368 [Epub ahead of print]

Anja Schwiebs, Heinfried H. Radeke: Immunopharmacological activity of betulin in inflammation-associated carcinogenesis. Anticancer Agents Medicinal Chemistry 2017 Oct 12. doi: 10.2174/1871520617666171012124820.[Epub ahead of print] (Review)

2017

Katrin G Schmidt, Martina Herrero San Juan, Sandra Trautmann, Lucija Berninger, Anja Schwiebs, Florian M Ottenlinger, Dominique Thomas, Frank Zaucke, Josef M Pfeilschifter, Heinfried H Radeke: Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. Frontiers in Immunology 2017 Sep 29;8:1242. doi: 10.3389/fimmu.2017.01242. eCollection 2017., DOI: 10.3389/fimmu.2017.01242

Jürgen Stein, Ayşegül Aksan, Karima Farrag, Axel Dignass, Heinfried H. Radeke: Management of inflammatory bowel disease-related anemia and iron deficiency with specific reference to the role of intravenous iron in current practice. Expert Opinion Pharmacotherapy 2017 Nov;18(16):1721-1737. doi: 10.1080/14656566.2017.1391790. Epub 2017 Nov 5. (Review)

Ayşegül Aksan, Hatice Işık, Heinfried H. Radeke, Axel Dignass, Jürgen Stein: Letter: the importance of dosing and baseline haemoglobin when establishing the relative efficacy of intravenous iron therapies-authors' reply. Alimentary Pharmacology and Therapeutics 2017 Oct;46(7):705-706. doi: 10.1111/apt.14269.

Ayşegül Aksan, Hatice Işık, Heinfried H. Radeke, Axel Dignass, Jürgen Stein: Letter: inconsistency in reporting of hypophosphataemia after intravenous iron-authors' reply. Alimentary Pharmacology and Therapeutics 2017 Sep;46(6):643-644. doi: 10.1111/apt.14254.

Ayşegül Aksan, Hatice Işık, Heinfried H. Radeke, Axel Dignass, Jürgen Stein: Editorial: which iron preparation for patients with IBD? Authors' reply. Alimentary Pharmacology and Therapeutics 2017 Jul;46(2):195-196. doi: 10.1111/apt.14126.

Stephanie Oertel, Klaus Scholich, Andreas Weigert, Dominique Thomas, Julia Schmetzer, Sandra Trautmann, Marthe-Susanna Wegner, Heinfried H. Radeke, Natalie Filmann, Bernhard Brüne, Gerd Geisslinger, Irmgard Tegeder, Sabine Grösch: Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cellular and Molecular Life Sciences 2017 Aug;74(16):3039-3055. doi: 10.1007/s00018-017-2518-9. Epub 2017 Apr 12.

Aysegül Aksan, Hatice Işık, Heinfried H. Radeke, Axel Dignass, Jürgen Stein: Systematic review with network meta-analysis: comparative efficacy and tolerability of different intravenous iron formulations for the treatment of iron deficiency anaemia in patients with inflammatory bowel disease. Alimentary Pharmacology and Therapeutics 2017 May;45(10):1303-1318., DOI:10.1111/apt.14043 (Review) Download PDF

Cornelia Richter, Martina Herrero San Juan, Benno Weigmann, Dominik Bergis, Katrin Dauber, Michael H Muders, Gustavo B Baretton, Josef M Pfeilschifter, Halvard Bonig, Sebastian Brenner, Heinfried H Radeke: Defective IL-23/IL-17 Axis Protects p47phox−/− Mice from Colon Cancer. Frontiers in Immunology 01/2017; 8(44)., DOI:10.3389/fimmu.2017.00044 Download PDF

Julia Martin, Heinfried H. Radeke, Axel Dignass, Jürgen Stein: Current evaluation and management of anemia in patients with inflammatory bowel disease. Expert Review of Gastroenterology and Hepatology 01/2017; 11(1)., DOI:10.1080/17474124.2017.1263566 (Review)

2016

Katharina Heim, Benjamin Dälken, Stefanie Faust, Faiza Rharbaoui, Andre Engling, Holger Wallmeier, Theodor Dingermann, Heinfried H Radeke, Jörg Schüttrumpf, Marcus Gutscher: High thioredoxin-1 levels in rheumatoid arthritis patients diminish binding and signalling of the monoclonal antibody Tregalizumab. Clinical Translational Immunology. 12/2016; 5(12):e121., DOI:10.1038/cti.2016.69 Download PDF

Florian M Ottenlinger, Christoph Alexander Mayer, Nerea Ferreirós, Yannick Schreiber, Anja Schwiebs, Katrin G Schmidt, Hanns Ackermann, Josef M Pfeilschifter, Heinfried H Radeke: Interferon-Beta Increases Plasma Ceramides of Specific Chain Length in Multiple Sclerosis Patients, Unlike Fingolimod or Natalizumab. Frontiers in Pharmacology 12/2016; 7(7):412-412., DOI:10.3389/fphar.2016.00412 Download PDF

Anja Schwiebs, Olga Friesen, Elisabeth Katzy, Nerea Ferreirós, Josef M Pfeilschifter, Heinfried H Radeke: Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1. Frontiers in Pharmacology 04/2016; 94((Suppl.))., DOI:10.3389/fphar.2016.00094 Download PDF

Florian Ottenlinger, Anja Schwiebs, Kathrin Pfarr, Annika Wagner, Sophia Grüner, Christoph A. Mayer, Josef M Pfeilschifter, Heinfried H Radeke: Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes. European Journal of Immunology 04/2016; 46(4):941-51., DOI:10.1002/eji.201545805 Download PDF

Katja Zschiebsch, Caroline Fischer, Geethanjali Pickert, Annett Häeussler, Heinfried Radeke, Sabine Grösch, Nerea Ferreirós, Gerd Geisslinger, Ernst R. Werner, Irmgard Tegeder: Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling. Journal of Crohn s and Colitis 02/2016; 10(8):jjw056., DOI:10.1093/ecco-jcc/jjw056 Download PDF

Dominik Bergis, Valentin Kassis, Heinfried H. Radeke: High plasma sST2 levels in gastric cancer and their association with metastatic disease. Cancer biomarkers: section A of Disease markers 01/2016; 16(1):117-125., DOI:10.3233/CBM-150547

2015

Annika Wagner, Michaela Köhm, Annica Nordin, Elisabet Svenungsson, Josef M. Pfeilschifter, Heinfried H. Radeke: Increased Serum Levels of the IL-33 Neutralizing sST2 in Limited Cutaneous Systemic Sclerosis. Scandinavian Journal of Immunology 2015 Sep;82(3):269-74. DOI:10.1111/sji.12317. Download PDF

Catherine Olesch, Weixiao Sha, Carlo Angioni, Lisa Katharina Sha, Elias Açaf, Paola Patrignani, Per-Johan Jakobsson, Heinfried H Radeke, Sabine Grösch, Gerd Geisslinger, Andreas von Knethen, Andreas Weigert, Bernhard Brüne: MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer. Oncotarget 03/2015; 6(12)., DOI:10.18632/oncotarget.3581 Download PDF

Kathrin Pfarr, Corina Danciu, Olga Arlt, Christina Neske, Cristina Dehelean, Josef M Pfeilschifter, Heinfried H Radeke: Simultaneous and Dose Dependent Melanoma Cytotoxic and Immune Stimulatory Activity of Betulin. PLoS ONE 03/2015; 10(3-3):e0118802., DOI:10.1371/journal.pone.0118802 Download PDF

Corina Danciu, Camelia Oprean, Dorina E Coricovac, Cioca Andreea, Anca Cimpean, Heinfried Radeke, Codruta Soica, Cristina Dehelean: Behaviour of four different B16 murine melanoma cell sublines: C57BL/6J skin. International Journal of Experimental Pathology 02/2015; 96(2). DOI:10.1111/iep.12114 Download PDF

Matthias Schröder, Olga Arlt, Helmut Schmidt, Andrea Huwiler, Carlo Angioni, Josef M Pfeilschifter, Anja Schwiebs, Heinfried H Radeke: Subcellular distribution of FTY720 and FTY720-phosphate in immune cells – another aspect of Fingolimod action relevant for therapeutic application. Biological Chemistry 01/2015; DOI:10.1515/hsz-2014-0287 Download PDF

Bianca Helling, Martin König, Benjamin Dälken, Andre Engling, Wolfgang Krömer, Katharina Heim, Holger Wallmeier, Jürgen Haas, Brigitte Wildemann, Brigitte Fritz, Helmut Jonuleit, Jan Kubach, Theodor Dingermann, Heinfried H Radeke, Frank Osterroth, Christoph Uherek, Niklas Czeloth, Jörg Schüttrumpf: A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway. Immunology and Cell Biology 2015 Apr;93(4):396-405. doi: 10.1038/icb.2014.102 Download PDF

Sabrina M. Mauf, Marissa Penna-Martinez, Thorsten Jentzsch, Hanns Ackermann, Dirk Henrich, Heinfried H. Radeke, Patrick Brück, Klaus Badenhoop, Elizabeth Ramos-Lopez: Immunomodulatory effects of 25-hydroxyvitamin D3 on monocytic cell differentiation and influence of vitamin D3 polymorphisms in type 1 diabetes. The Journal of Steroid Biochemistry and Molecular Biology 2015 Mar;147:17-23. doi: 10.1016/j.jsbmb.2014.11.001

2014

Katja Rüger, Florian Ottenlinger, Matthias Schröder, Aleksandra Živković, Holger Stark, Josef M. Pfeilschifter, Heinfried H. Radeke: Modulation of IL-33/ST2-TIR and TLR Signalling Pathway by Fingolimod and Analogues in Immune Cells. Scandinavian Journal of Immunology 09/2014; 80(6). DOI:10.1111/sji.12238 Download PDF

Olga Arlt, Anja Schwiebs, Lukasz Japtok, Katja Rüger, Elisabeth Katzy, Burkhard Kleuser, Heinfried H Radeke: Sphingosine-1-Phosphate Modulates Dendritic Cell Function: Focus on Non-Migratory Effects in Vitro and in Vivo. Cellular Physiology and Biochemistry 06/2014; 34(1):27-44., DOI:10.1159/000362982 (Review) Download PDF

Christopher Ungerer, Patricia Christina Quade-Lyssy, Heinfried H Radeke, Reinhard Henschler, Christoph Königs, Ulrike Köhl, Erhard Seifried, Jörg Schüttrumpf: Galectin-9 Is a Suppressor of T and B Cells and Predicts the Immune Modulatory Potential of Mesenchymal Stromal Cell Preparations. Stem cells and development 03/2014; 23(7):755-66., DOI:10.1089/scd.2013.0335 Download PDF

2013

Corina Danciu, Alexandra Falamas, Cristina Dehelean, Codruta Soica, Heinfried Radeke, Lucian Barbu-Tudoran, Florina Bojin, Simona Cînt Pînzaru: A characterization of four B16 murine melanoma cell sublines molecular fingerprint and proliferation behavior. Cancer Cell International 07/2013; 13(1):75., DOI:10.1186/1475-2867-13-75 Download PDF

Oliver Giegold, Nadine Ogrissek, Heinfried H Radeke: Response to Comment on "CXCL9 Causes Heterologous Desensitization of CXCL12-Mediated Memory T Lymphocyte Activation". The Journal of Immunology 07/2013; 191(2):525-6., DOI:10.4049/jimmunol.1390037 (Comment) Download PDF

Dominik Bergis, Valentin Kassis, Annika Ranglack, Verena Koeberle, Albrecht Piiper, Bernd Kronenberger, Stefan Zeuzem, Oliver Waidmann, Heinfried H Radeke: High Serum Levels of the Interleukin-33 Receptor Soluble ST2 as a Negative Prognostic Factor in Hepatocellular Carcinoma. Translational oncology 06/2013; 6(3):311-8., DOI:10.1016/S0168-8278(13)60632-7 Download PDF

Oliver Giegold, Nadine Ogrissek, Cornelia Richter, Matthias Schröder, Martina Herrero San Juan, Josef M Pfeilschifter, Heinfried H Radeke: CXCL9 Causes Heterologous Desensitization of CXCL12-Mediated Memory T Lymphocyte Activation. The Journal of Immunology 02/2013; 190(7)., DOI:10.4049/jimmunol.1101293 Download PDF

Frances Brauer, Kerstin Schmidt, Roland C Zahn, Cornelia Richter, Heinfried H Radeke, Jörn E Schmitz, Dorothee von Laer, Lisa Egerer: A Rationally Engineered Anti-HIV Peptide Fusion Inhibitor with Greatly Reduced Immunogenicity. Antimicrobial Agents and Chemotherapy 2013 Feb;57(2):679-88. DOI: 10.1128/AAC.01152-12 Download PDF

2012

Lukasz Japtok, Katrin Schaper, Wolfgang Bäumer, Heinfried H Radeke, Se Kyoo Jeong, Burkhard Kleuser: Sphingosine 1-Phosphate Modulates Antigen Capture by Murine Langerhans Cells via the S1P2 Receptor Subtype. PLoS ONE 11/2012; 7(11):e49427., DOI:10.1371/journal.pone.0049427 Download PDF

Nerea Ferreirós, S Labocha, Matthias Schröder, Heinfried H. Radeke, Gerd Geisslinger: LC-MS/MS determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 03/2012; 887-888:122-7., DOI:10.1016/j.jchromb.2012.01.023

Kerstin C Reuter, Christian R Grunwitz, Bettina M Kaminski, Dieter Steinhilber, Heinfried H Radeke*, Jürgen Stein*: Selective Glucocorticoid Receptor Agonists for the Treatment of Inflammatory Bowel Disease: Studies in Mice with Acute Trinitrobenzene Sulfonic Acid Colitis. Journal of Pharmacology and Experimental Therapeutics 01/2012; 341(1):68-80., *) two authors contributed equally. DOI:10.1124/jpet.111.183947 Download PDF

2011

Verena Bihrer, Oliver Waidmann, Mireen Friedrich-Rust, Nicole Forestier, Simone Susser, Jörg Haupenthal, Martin Welker, Ying Shi, Jan Peveling-Oberhag, Andreas Polta, Michael von Wagner, Heinfried H Radeke, Christoph Sarrazin, Jörg Trojan, Stefan Zeuzem, Bernd Kronenberger, Albrecht Piiper: Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma. PLoS ONE 10/2011; 6(10):e26971., DOI:10.1371/journal.pone.0026971 Download PDF

Verena Bihrer, Mireen Friedrich-Rust, Bernd Kronenberger, Nicole Forestier, Jörg Haupenthal, Ying Shi, Jan Peveling-Oberhag, Heinfried H Radeke, Christoph Sarrazin, Eva Herrmann, Stefan Zeuzem, Oliver Waidmann, Albrecht Piiper: Serum miR-122 as a Biomarker of Necroinflammation in Patients With Chronic Hepatitis C Virus Infection. The American Journal of Gastroenterology 05/2011; 106(9):1663-9., DOI:10.1038/ajg.2011.161 Download PDF

Matthias Schröder, Cornelia Richter, Martina Herrero San Juan, Katrin Maltusch, Oliver Giegold, Gianluca Quintini, Josef M Pfeilschifter, Andrea Huwiler, Heinfried H Radeke: The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. Molecular Immunology 03/2011; 48(9-10):1139-48., DOI:10.1016/j.molimm.2011.02.007

More Articles in 2010

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